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FAQ



  1. How are PARS-assisted structure predictions generated and how are they displayed?

    To generate the PARS-assisted structure predictions, we provide the prediction algorithm (Vienna's RNAfold) constraints extracted from our experimental measurement. Namely, nucleotides having a high PARS score (>5) are constrained to be double-stranded whereas nucleotides having low PARS scores (<-5) are constrained to be single-stranded. Technically, this is done by using the constraints options (-C flag) of RNAfold version 1.6. Those nucleotides that were used as constraints are circled in the RNA structure plot shown at the browse catalogs section and in iPARS.